Manu is home to local people including: native communities, colonists from the highlands, and native groups living a traditional life in isolation.
Otros grupos nativos
Other groups living in the Amazonian lowlands include the Yine who live in the community of Diamante in the buffer zone and the Harakmbut who live primarily in or near the village of Shintuya on the Alto Madre de Dios River.
Additionally, Nahua and Yora visit remoter areas of the park in the headwaters of the Manu River to harvest turtle eggs and fish. The Andean highlands in the Mapacho river valley are home to Quechua speaking communities that cultivate potatoes, maize, fruits, and coffee. These communities border the park with the exception of Callanga that is found at the site of an old Hacienda within the park.